Heavyweight champion Anthony Joshua made his long-awaited United States debut against late replacement Andy Ruiz Jr. at Madison Square Garden in 2019. After knocking Ruiz down in the third round, the tables were dramatically turned on Joshua as Ruiz floored the champion four times before securing a stunning seventh-round TKO victory. One of the biggest upsets in boxing history, the victory saw Ruiz became the first boxer of Mexican heritage to win a world heavyweight title.